ОНТОЛОГІЧНА МОДЕЛЬ ПРОЦЕСІВ ПРОГРАМОВАНОЇ КЛІТИННОЇ ЗАГИБЕЛІ

O. P. Mintser, D. V. Vatlitsov

Анотація


Структурною одиницею життя на землі є клітина. Важливим аспектом існування клітини, як одиниці життя, є її здатність до елімінації нежиттєздатних або дефектних одиниць з системи без пошкодження інших одиниць. Проведені дослідження виявили зростання кількості робіт, присвячених системним дослідженням програмованої клітинної загибелі. Виходячи з результатів проведеного аналізу літературних джерел формалізовано схему та описано рівні організації, на яких можливе виникнення «події», яка ініціює каскади, що призводять до настання ПКЗ. Також було виявлено основні напрямки розвитку досліджень, переважна кількість котрих охоплюють рівні вище молекулярної взаємодії, згідно з запропонованою нами онтологічною моделлю програмованої клітинної загибелі. Виявлено біфуркаційну природу проходження сигналу ПКЗ та окреслено роль компонентів, віднесених нами до рівнів нижче молекулярної взаємодії. На основі цих даних запропоновано маркери розвитку та способи управління процесами ПКЗ через контроль концентрації іонів промоутерів та інгібіторів. Результати даного дослідження є підґрунтям для системного вивчення шляхів виникнення, розвитку та управління активного каскаду ПКЗ.

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DOI: http://dx.doi.org/10.11603/mie.1996-1960.2015.2.4906

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